- ANO1 / DOG1 / TMEM16A Recombinant Monoclonal Antibody
- LSBio
- Pricing InfoSupplier PageView Company Product Page
- LS-B16310
- IHC-Fx
- Unconjugated
- 10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
- Protein A/G purified
- Human
- ANO1 / DOG1 / TMEM16A
- IgG
- DG1/2564R
- Rabbit
- aa 2-101
- anoctamin 1
- DOG1, INDMS, ORAOV2, TAOS2, TMEM16A
- Recombinant Monoclonal
- 100 µg
Specifications/Features
Specificity: The expression of DOG1 is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GISTs. Overexpression of DOG1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%